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What supplements, nutrients or herbs have been studied for Arthritis?

Curcumin / Curcuma longa extract / turmeric extracts: 120 mg to 1500 mg; Collagen / collagen-based supplements / collagen peptides / undenatured type II collagen: 40 mg daily for undenatured type II collagen; 10 g/day and 20 g/day collagen peptides; other collagen-based supplements not specified in abstract; Glucosamine and chondroitin: 1500 mg glucosamine and 1200 mg chondroitin daily in the trial abstract; broader dose details not specified in review abstract. Across the abstracts, the arthritis literature is dominated by randomized trials and meta-analyses of collagen products, curcumin/turmeric, and glucosamine/chondroitin, especially for osteoarthritis. Several other natural products were studied more narrowly, including ginger, Boswellia serrata, pycnogenol, L-carnitine, green-lipped mussel, krill oil, vitamin D, omega-3 fatty acids, and multiple dietary polyphenols in rheumatoid arthritis. Overall, the evidence base includes a mix of positive symptom findings, neutral findings, and a few broader systematic reviews, with the strongest concentration of data in osteoarthritis and rheumatoid arthritis. Some abstracts report improvements in pain, function, stiffness, inflammation, or disease activity, while others show no benefit compared with placebo. This evidence is educational; it is not FDA-approved and is not medical advice.

¿Qué suplementos, nutrientes o hierbas se han estudiado para Artritis?

Cúrcuma longa / curcumina / extracto de cúrcuma: 120 mg a 1500 mg; en los ensayos incluidos se reportaron varias formas de curcumina y extracto de Curcuma longa, sin más especificación consistente en el resumen; Colágeno: No especificado en el resumen para todos los estudios incluidos; Colágeno tipo II no desnaturalizado: 40 mg al día. La evidencia publicada en estos resúmenes se concentra sobre todo en osteoartritis y artritis reumatoide, con varias revisiones sistemáticas y ensayos clínicos aleatorizados. Los compuestos estudiados con mayor frecuencia incluyen curcumina/extracto de Curcuma longa, colágeno, colágeno tipo II no desnaturalizado, glucosamina y condroitina, además de jengibre, boswellia, omega-3, vitamina D y aceite de kril. En general, los metaanálisis describen mejoras en dolor y función para algunos de estos productos, aunque varios trabajos señalan que los resultados varían según el comparador y que la calidad de la evidencia es limitada o heterogénea. También hubo estudios con hallazgos nulos, como el aceite de kril en dolor de rodilla y el omega-3 en algunos parámetros de osteoartritis. Esta evidencia es educativa; no está aprobada por la FDA y no constituye consejo médico.

Evidence by health condition

Nutrients, herbs & natural products studied for Arthritis

14 PubMed clinical trials & meta-analyses analyzed

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AI summary

Evidence stage: Meta-Analysis

Across the abstracts, the arthritis evidence base is dominated by human clinical trials and meta-analyses, especially for osteoarthritis and rheumatoid arthritis. Collagen-based supplements, curcumin/Curcuma longa extract, glucosamine/chondroitin, omega-3 fatty acids, and vitamin D were the most commonly studied compounds, with several reviews reporting improvements in pain, function, or inflammatory markers. Some individual trials were negative or mixed, such as krill oil for knee osteoarthritis, which did not improve pain versus placebo. Overall, the literature suggests that findings vary by compound, arthritis type, and outcome measured, and many interventions still have limited or low-quality evidence. This evidence is educational; it is not FDA-approved and is not medical advice.

Doses are those reported in the studies, not recommendations. Talk to your doctor before taking anything.

Collagen

Natural productModerate evidenceMeta-Analysis

Doses studied: Not specified in abstract

Duration: Not specified

Meta-analyses of randomized trials in knee osteoarthritis reported significant improvements in function and pain scores with oral collagen-based supplements versus placebo. One meta-analysis reported a reduction in total WOMAC score, and another found a significant decrease in stiffness, while pain and function results were not consistently significant across all analyses. The 2025 meta-analysis included 870 participants from 11 RCTs and found favorable pooled effects on both function and pain.

Sources:PMID 39212129 PMID 30368550

Curcumin / Curcuma longa extract / turmeric extracts

HerbModerate evidenceMeta-Analysis

Doses studied: 120 mg to 1500 mg

Duration: 4-36 weeks

Multiple systematic reviews and meta-analyses evaluated curcumin and Curcuma longa extract in arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, and gout/hyperuricemia. The abstracts report improvements in pain and inflammation outcomes, including reductions in visual analog pain scores and WOMAC measures in osteoarthritis, with generally comparable safety to placebo and some lower adverse event rates versus NSAIDs. Evidence quality was described as low in at least one review, and more randomized trials were noted as needed.

Sources:PMID 35935936 PMID 34017975 PMID 27533649

+14 more compounds studied

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