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What supplements, nutrients or herbs have been studied for Gout & Uric Acid?

Curcumin / Curcuma longa extract: 120 mg to 1500 mg; Probiotic Probio-X: 3 × 10^10 CFU/day; Alpha-linolenic acid: Not specified in abstract. The abstracts show a small but diverse evidence landscape for gout and uric acid involving curcumin/Curcuma longa extract, probiotics, and observational evidence around alpha-linolenic acid, with one systematic review also summarizing dietary supplements in chronic gout more broadly. The most direct interventional evidence in gout comes from a probiotic trial of Probio-X and from a meta-analysis that included gout/hyperuricemia among arthritis conditions studied for curcumin and Curcuma longa extract. Separately, a chronic gout systematic review evaluated a broad set of supplements but did not report specific compound-level results in the abstract. Other abstracts provide only indirect or non-gout evidence related to uric acid as a biomarker or risk factor in other conditions. This evidence is educational; it is not FDA-approved and is not medical advice.

¿Qué suplementos, nutrientes o hierbas se han estudiado para Gota y Ácido Úrico?

Curcumina / extracto de Curcuma longa: 120 mg a 1500 mg; Probio-X: 3 × 10^10 UFC/día; Suplementos dietéticos en general: No especificado en el resumen. La evidencia identificada para gota y ácido úrico se centra sobre todo en estudios de curcumina/Curcuma longa y en un ensayo con un probiótico específico. También aparece una revisión Cochrane sobre suplementos para gota crónica, pero el resumen no aporta resultados específicos por nutriente en el fragmento disponible. En el estudio con probiótico, la coadministración con febuxostat se asoció con cambios favorables en ácido úrico sérico y en la tasa de ataques agudos, junto con modificaciones en microbiota y metabolitos fecales en los respondedores. Para curcumina y extracto de Curcuma longa, el metaanálisis incluyó ensayos en artritis con subgrupo de gota/hiperuricemia y describió mejoría global de dolor e inflamación. Esta evidencia es educativa; no está aprobada por la FDA y no constituye consejo médico.

Evidence by health condition

Nutrients, herbs & natural products studied for Gout & Uric Acid

14 PubMed clinical trials & meta-analyses analyzed

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AI summary

Evidence stage: Meta-Analysis

The abstracts describe a small and heterogeneous evidence base for gout and uric acid outcomes, ranging from randomized trials to systematic reviews and meta-analyses. The strongest recurring theme is Chinese herbal medicine used externally or as formula compounds, with multiple reviews reporting improvements in pain, overall efficacy, inflammation, and uric acid-related outcomes in acute gouty arthritis. One randomized trial also reported that Zhifang I Decoction decreased serum uric acid in people with nonalcoholic fatty liver disease complicated by hyperuricemia. Outside herbal compounds, vitamin D and alpha-lipoic acid were studied in unrelated populations and did not show significant uric acid changes in the reported abstracts, while nicotinic acid was observed to increase plasma uric acid. This evidence is educational; it is not FDA-approved and is not medical advice.

Doses are those reported in the studies, not recommendations. Talk to your doctor before taking anything.

Chinese herbal compounds (external use for acute gouty arthritis)

HerbModerate evidenceMeta-Analysis

Doses studied: Not specified in abstract

Duration: Not specified

A 2023 systematic review/meta-analysis included 27 randomized controlled trials with 1951 participants and evaluated total effective rate, uric acid level, pain score, and inflammatory factors such as erythrocyte sedimentation rate and C-reactive protein. Across the pooled studies, the external-use herbal medicine groups showed significantly better outcomes than western medicine controls for pain, inflammation, and uric acid levels. Side effects were reported in some studies, and when reported, the intervention groups had fewer complications than controls.

Sources:PMID 37713880

Chinese herbal compounds (acute gouty arthritis, oral/combined Chinese herbal formulas)

HerbModerate evidenceMeta-Analysis

Doses studied: Not specified in abstract

Duration: Not specified

A 2025 systematic review/meta-analysis included 28 studies with 2100 participants and found that Chinese herbal compounds improved overall efficacy compared with conventional western medicine. The meta-analysis also reported improvement in visual analogue scale scores and serum uric acid levels, with the evidence graded as very low. Blood sedimentation-related outcomes were also assessed, but the abstract is truncated before all details are listed.

Sources:PMID 39923577

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