Nutrients, herbs & natural products studied for Thyroid (Hashimoto)
14 PubMed clinical trials & meta-analyses analyzed
AI summary
Evidence stage: Meta-AnalysisAcross these abstracts, selenium was the most frequently studied nutrient for Hashimoto thyroiditis, usually with outcomes focused on thyroid autoantibodies, TSH, and thyroid hormone levels. Vitamin D was also evaluated in multiple randomized studies and in meta-analyses, with effects assessed on TPO-Ab, Tg-Ab, TSH, FT3, and FT4. Other individual interventions included myo-inositol alone or combined with selenium, ashwagandha root extract, Nigella sativa, and a synbiotic formulation containing probiotics plus fructo-oligosaccharide. One trial also examined combined zinc, magnesium, and vitamin A supplementation, and a pilot study looked at vitamin C in hypothyroid patients requiring high-dose levothyroxine. This evidence is educational; it is not FDA-approved and is not medical advice.
Doses are those reported in the studies, not recommendations. Talk to your doctor before taking anything.
Selenium
NutrientStrong evidenceMeta-AnalysisDoses studied: Not specified in abstract
Duration: 3 months, 6 months, or 6 months in included studies; exact dosing not specified in abstract
Meta-analyses and randomized trials reported that selenium supplementation was associated with lower thyroid autoantibody titers, especially TPOAb and TgAb, and some analyses also found lower TSH. One randomized trial using selenious yeast tablet reported decreases in TPOAb, TgAb, and TSH, with increases in Se, GPx3, and SePP1. The 2025 meta-analysis also noted that selenomethionine appeared more effective than NaSe and Se-yeast in the included studies.
Vitamin D
NutrientModerate evidenceMeta-AnalysisDoses studied: Not specified in abstract
Duration: Not specified in abstract; one included analysis mentioned 6-month treatment
Systematic review and meta-analysis found vitamin D supplementation was associated with reductions in TPO-Ab and Tg-Ab, and increases in FT3 and FT4, with a small decrease in TSH reported. The network meta-analysis included vitamin D among supplements studied in euthyroid Hashimoto thyroiditis, but reported that vitamin D alone did not effectively reduce TPOAb during 6 months in the cited comparison. The abstract also mentions active vitamin D (calcitriol) but does not provide the full comparative result.
+6 more compounds studied
Unlock every compound with doses, duration, findings and sources.
Unlock with Premium